Our research focused on microbial systematics and evolution. Based on the next-generation sequencing techniques and the increasing genomic data, we attempted to investigate the evolution and speciation of some specific taxa, by using phylogenomic and comparative genomic approaches; reveal the evolutionary history of the relative enzymes belonging to various metabolic pathways; investigate the ecological adaptation mechanisms of prokaryotes from genomic and proteomic level.
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Lolamicin, targeting the lipoprotein transport system, has activity against a panel of more than 130 multidrug-resistant clinical isolates, shows efficacy in multiple mouse models of acute pneumonia and septicaemia infection, and spares the gut microbiome in mice, preventing secondary infection with Clostridioides difficile. from: Muñoz et al., Nature. 2024. DOI:10.1038/s41586-024-07502-0 |
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The authors found that eukaryotes are placed, with high confidence, as a well-nested clade within Asgard archaea and as a sister lineage to Hodarchaeales, a newly proposed order within Heimdallarchaeia. from: Eme et al., Nature. 2023; 618(7967): 992-999. DOI:10.1038/s41586-023-06186-2 |
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Tang et al. report that a group of the family Halobacteriaceae display a life cycle resembling that of Streptomyces bacteria. from: Tang et al., Nat Commun. 2023; 14:1827. DOI:10.1038/s41467-023-37389-w |
